Targeting intrinsically disordered proteins involved in cancer.

We describe the outcomes of using these approaches in targeting IDPs involved in cancer, in the view to providing insight, to target IDPs in general. In a broad sense, the designed small molecules seem to target the most hydrophobic regions of the IDPs, hampering macromolecule (DNA or protein)-IDP interactions; furthermore, in most of the molecule-IDP complexes described so far, the protein remains disordered. PMID: 31667555 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31667555?dopt=Abstract

Source: Cellular and Molecular Life Sciences : CMLS - October 29, 2019 Category: Cytology Authors: Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Neira JL, Iovanna J Tags: Cell Mol Life Sci Source Type: research