Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits.
CONCLUSIONS: Our study shows that the diabetes risk variant rs10830963 does not contribute to the known comorbidity between depression and type 2 diabetes. Key messages The association between depression and type 2 diabetes is bidirectional. We tested whether a common variant rs10830963 in the gene encoding Melatonin Receptor 1B influences the known association between depressive symptoms and glycaemic traits in a population-based sample from Western Finland. The MTNR1B genetic diabetes risk variant rs10830963 does not contribute to the known comorbidity between depression and type 2 diabetes. Depressive symptoms and rs10830963 are associated with a worse glycaemic profile independently of each other.
PMID: 30089436 [PubMed - indexed for MEDLINE]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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