5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes [Molecular Diagnostics and Genetics]

CONCLUSIONS:
The 5hmC markers in cfDNA reflected the epigenetic changes in patients with T2D who developed macrovascular/microvascular complications. The 5hmC-Seal assay has the potential to be a clinically convenient, noninvasive approach that can be applied in the clinic to monitor the presence and severity of diabetic vascular complications.

Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Yang, Y., Zeng, C., Lu, X., Song, Y., Nie, J., Ran, R., Zhang, Z., He, C., Zhang, W., Liu, S.-M. Tags: Molecular Diagnostics and Genetics Source Type: research