Cooperative Immune-mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL-15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy.

CONCLUSIONS: Collectively, these data demonstrate that the synergistic combination of entinostat, N-803, and vaccine elicits potent anti-tumor activity by generating a more inflamed TME. These findings thus form the rationale for the use of this combination of agents for patients harboring poorly or non-inflamed solid carcinomas. PMID: 31645354 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research