Well: Study Finds No Vaccine Link to Guillain-Barré
Concerns about vaccines and the neurological disorder Guillain-Barré syndrome arose after the swine flu epidemic of 1976, but a new analysis found no link between the illness and vaccines for flu or other disorders.
In this study, aqueous suspensions of various active ingredients (A.I.s) were utilized to generate Engineered Water Nanostructures (EWNS) nano-sanitizers, containing the A.I. utilized to produced them (termed iEWNS). These iEWNS had nanoscale size, were loaded with ROS and contained the A.I. utilized to produce them. They were challenged with Influenza H1N1/PR/8 and Acinetobacter baumannii on surfaces and in air. The results indicate that a nanogram dose of A.I. is effective in producing significant inactivation in Influenza H1N1/PR/8 and Acinetobacter baumannii.
Considering the opioid epidemic, safe alternatives to opioids for pain management is paramount. Effective non-pharmacological management of chronic pain requires individuals to initiate and maintain healthy behavior changes over time. To facilitate behavioral change, an in-depth understanding of mechanisms of action underlying the intervention is required. Supported by the National Institutes of Health (NIH) Common Fund, the Science of Behavior Change (SOBC) program seeks to make behavior change research more impactful, targeted, and systematic by promoting a common, mechanism-focused, experimental medicine approac...
Opioid misuse, particularly among those with chronic pain, constitutes a significant public health problem and is associated with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids remain the most widely prescribed class of medications. Prescription opioids are often used to treat chronic pain despite the risks associated with use, and chronic pain remains an important factor in understanding this epidemic. Cannabis is another substance that has recently garnered attention in the chronic pain literature, as increasing numbers of individuals use cannabis to manage chronic pain.
The widespread misuse and abuse of prescribed opioid pain relievers amongst chronic pain patients is a central contributor to the opioid epidemic. The current study aimed to identify potential risk factors and treatment targets that may reduce and prevent opioid misuse. The NIH's Patient Reported Outcomes Measurement Information System (PROMIS)-Abuse of Prescription Medication item bank (Rx-Abuse) was validated in both community and clinical samples to assess self-reported severity of medication abuse.
The experience of pain is different for everyone and there is considerable variability regarding pain perceptions. The recent opioid epidemic is a major source of stress for patients and clinicians alike. There is a significant need for comprehensive pain assessment and nonpharmacological treatments for pain. However, research suggests that nurses experience barriers related to the assessment and treatment of patients ’ pain. Such barriers may include not having enough time to work with patients, subjective pain assessments, medication-seeking behaviors, and lack of support from treating physicians.
Acute neuropathic pain (ANP) resulting from civilian and combat traumatic injuries has dramatic impact on society at large as it poses with significant personal and economic burden. With opioid abuse epidemic currently in public eye across all levels of society, it is pertinent new therapeutic modalities are needed to effectively treat and resolve ANP. Neuroinflammation is recognized as one of the primary drivers of acute neuropathic to chronic pain transition leading to prolonged disability and loss of productivity.
The utilization of complementary care is on the rise for patients with chronic pain, partly due to the opioid epidemic and recent guidelines stating opioids are ineffective for chronic pain. Physical activity is a primary recommendation for various types of chronic pain. The 2007 National Health Interview Survey found that U.S. adults are choosing yoga as one of the top 10 complementary approaches. Stemming from ancient Indian philosophy, yoga is a mind-body practice that typically combines physical postures, breathing techniques and meditation.
In this study, we evaluate the effectiveness of a Codeine preparation for the treatment of moderate to severe pain.
The chronic pain and opioid epidemics have created an urgent need for effective, non-opioid analgesics. There is considerable evidence that the cholinergic system could be a promising target for novel drugs. Cholinesterase inhibitors and nonspecific muscarinic acetylcholine receptor (mAChR) agonists are clearly antinociceptive in humans and animal models, but adverse parasympathetic side effects limit clinical utility. The mAChR family includes five subtypes (M1-M5) with different physiologic roles. Prior studies indicate that the M2 and M4 subtypes mediate analgesia, while the M2 and M3 subtypes mediate most deleterious side effects.
In March 2016, in response to a national opioid epidemic, the CDC released guidelines for prescribing opioids for chronic pain. Pain Specialists at a comprehensive, interdisciplinary Pain Clinic within an integrated health system in suburban Minneapolis, Minnesota - a Clinic designed in large part to respond to the opioid epidemic - evaluated patients for participation in a pain treatment program with emphasis on SELF- ve rsus MEDICATION-management of their chronic pain. While recognizing success in the Pain Clinic (95% of the patients had maintained decreased opioid use, and 38% of the patients showed a 100% ...