ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue.

In this study, we hypothesized that ACE2 exerts a strong anti-obesity effect by increasing Ang1-7 levels. We injected intraperitoneally recombinant human ACE2 (rhACE2) (2.0mg/ kg/day) for 28 days to high-fat diet (HFD) induced obesity mice. rhACE2 treatment decreased body weight and improved glucose metabolism. Furthermore, rhACE2 increased oxygen consumption and upregulated thermogenesis in HFD-fed mice. In the rhACE2 treatment group, BAT mass increased, accompanied with ameliorated insulin signaling and increased protein levels of UCP-1 and PRDM16. Importantly, subcutaneous white adipose tissue (sWAT) mass decreased, concomitant with browning, which was established by the increase of UCP-1 expression. The browning is due to increased H3K27 acetylation via the downregulation of HDAC3 and increased H3K9 acetylation via upregulation of GCN5 and PCAF. These results suggest that rhACE2 exerts anti-obesity effects by stimulating BAT and inducing browning in sWAT. ACE2 and the Ang 1-7 axis represent a potential therapeutic approach to prevent the development of obesity. PMID: 31638856 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research