Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method.

We report a longitudinal behavioral study in a methylazoxymethanol acetate (MAM) rat model of schizophrenia at three different age periods: prepuberty, late-puberty and early-adulthood. MAM-treated rats showed stable hypolocomotive activity, anxiety and cognitive deficits from late-puberty to early-adulthood. Therefore we detected the metabolites changes of adult MAM-treated rats using an in vitro proton nuclear magnetic resonance (1H-NMR) method. In the MAM-treated rats, glutamate was increased in the thalamus and hypothalamus, glutamine was increased in the hippocampus and GABA was increased in the hippocampus and prefrontal cortex, while taurine showed a decrease in the striatum, temporal cortex and parietal cortex. These abnormalities may be helped further understanding the pathophysiology of schizophrenia. PMID: 31632560 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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(Bar-Ilan University) Researchers examined the relationship between psychiatric diagnoses and future incarceration by merging data from psychiatric interviews that took place in the 1980s with 30 years of follow-up data. Among other things, they found that diagnoses of substance use and antisocial personality were predictors of future incarceration but that other psychiatric diagnoses (i.e., schizophrenia, affective disorders, anxiety disorders, as well as some other psychiatric disorders) were not independent predictors.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Conclusion: Future sham-controlled studies with large sample sizes are needed to definitively conclude on the clinical interest of mindfulness-based interventions in FEP patients and UHR individuals as well as to understand their underlying mechanisms of action.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
(Natural News) A recent study suggests that schizophrenia is often overdiagnosed in patients – when, in fact, they exhibit symptoms of anxiety. Researchers from Johns Hopkins University studied 78 patients referred to their Early Psychosis Intervention Clinic (EPIC) between February 2011 and July 2017. 54 of those 78 patients received a predetermined diagnosis of a schizophrenia spectrum disorder....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: Major limitations of the reviewed studies were short trial duration, small sample sizes, and the lack of control groups. Defining the potential role of DUL in the treatment of psychiatric disorders other than major depressive disorder and generalized anxiety disorder needs further randomized, placebo-controlled studies.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Introduction: More than half of psychiatric patients have comorbid substance use disorder (dual diagnosis) and this rate, confirmed by many epidemiological studies, is substantially higher compared to general population. Combined operation of self-medication mechanisms, common etiological factors, and mutually causative influences most likely accounts for comorbidity, which, despite its clinical prevalence, remains underrepresented in psychiatric research, especially in terms of neuroimaging. The current paper attempts to review and discuss all existing methodologically sustainable structural and functional neuroimaging st...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
RESUMO Objetivo Avaliar o efeito do internato em sa úde mental nas atitudes dos alunos de medicina quanto ao portador de transtorno mental (PTM). Métodos Atitudes foram avaliadas por questionário antes e depois do internato, por meio dos fatores: “ aceita ção social de PTM ” (F1), “ n ão acreditar em causas sobrenaturais para doença mental ” (F2), “ pap éis sociais comuns para PTM ” (F3), “ acreditar em causas psicossociais para doen ça mental ” (F4), “ intimidade ” (F5). Diferen ças foram avali...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
ConclusionsThe public ’s level of mental health literacy related to recognition of specific mental disorders, and knowledge and beliefs about treatments is still relatively low. The government should consider public education campaigns to improve this.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
ConclusionOC significantly improved mental health and executive function in individuals with schizophrenia. Further, OC significantly increased PA measured by the pedometers. These findings suggest that OC offers a safe and attrition-lowering intervention promoting mental health and PA.Trial registrationcris.nih.go.kr identifier: KCT-0000873
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Abstract Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aim to investigate shared genetic and the causal link between asthma and mental health disorders.We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from UK Biobank and 8 mental health disorders from Psychiatric Genomics Consortium, including: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir J Source Type: research
The word “schizophrenia” tends to conjure ideas of dramatic imagery: hallucinations, delusions, insane asylums in the general public’s mind. Most people don’t think of the boring parts that consume many with schizophrenia, like lacking the motivation to get out of bed, to make friends… Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard discuss avolition and ways to help motivate loved ones in this episode of Inside Schizophrenia. Family Counselor Ms. Breen joins to share ways to sort through dilemmas. And Rachel does an experiment on her own to address her lack of mo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Inside Schizophrenia Mental Health and Wellness Motivation and Inspiration Psychology avolition Lack Of Motivation Living With Schizophrenia Source Type: blogs
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