AIM2 Inflammasome Assembly and Signaling.

AIM2 Inflammasome Assembly and Signaling. Adv Exp Med Biol. 2019;1172:143-155 Authors: Wang B, Tian Y, Yin Q Abstract AIM2 (absent in melanoma 2) is a cytoplasmic sensor of double-stranded DNA from pathogens or damaged cellular organelles. It recruits ASC (apoptosis-associated specklike protein containing a CARD) and caspase-1 to form the AIM2 inflammasome, activate caspase-1, and elicit inflammatory responses via cytokine maturation and pyroptotic cell death. Structural studies from X-ray crystallography, NMR, and cryo-EM have revealed many details in AIM2 inflammasome activation, assembly, and regulation. Many principles learned from AIM2 inflammasome also apply to other inflammasomes. In this chapter, we discuss the interactions between dsDNA and AIM2-like receptors, between AIM2 and adaptor protein ASC, and between ASC and caspase-1 with the focus on helical filament assembly formed by PYD and CARD domains. PMID: 31628655 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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