Hydrogen Sulfide Regulation of Renal and Mesenteric Blood Flow.

Hydrogen Sulfide Regulation of Renal and Mesenteric Blood Flow. Am J Physiol Heart Circ Physiol. 2019 Oct 18;: Authors: Morales-Loredo H, Barrera A, Garcia J, Pace CE, Naik JS, Gonzalez-Bosc LV, Kanagy NL Abstract Hydrogen sulfide (H2S) dilates isolated arteries and knockout of the H2S synthesizing enzyme, cystathionine γ-lyase (CSE), increases blood pressure. However, the contributions of endogenously produced H2S to blood flow regulation in specific vascular beds is unknown. Published studies in isolated arteries show that CSE production of H2S influences vascular tone more in small mesenteric arteries than in renal arteries or the aorta. Therefore, the goal of this study was to evaluate H2S regulation of blood pressure, vascular resistance and regional blood flows using chronically instrumented rats. We hypothesized that during whole animal CSE inhibition, vascular resistance would increase more in the mesenteric than the renal circulation. Under anesthesia, CSE inhibition (β-cyanoalanine, BCA, 30 mg/kg bolus + 5 mg/kg/min for 20 minute i.v.) rapidly increased MAP more than saline administration (% D: saline -1.4±0.75 vs BCA 7.1±1.69, p<0.05) but did not change resistance (MAP/flow) in either the mesenteric or renal circulation. In conscious rats, BCA infusion similarly increased MAP (% D: saline -0.8±1.18 vs BCA 8.2±2.6, p<0.05, n=7) and significantly increased mesenteric resistance (saline 0.9±3.1 vs BCA 15.6±6.5, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research