Multi-day maintenance of extracorporeal lungs using cross-circulation with conscious swine

Lung remains the least utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex-vivo perfusion systems are limited to less than 24 hours of support. Here, we demonstrate the feasibility of extending normothermic extracorporeal lung support to 4 days using cross-circulation with conscious swine.

Source: The Journal of Thoracic and Cardiovascular Surgery - October 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Ahmed E. Hozain, Yuliya Tipograf, Meghan R. Pinezich, Katherine M. Cunningham, Rachel Donocoff, Dawn Queen, Kenmond Fung, Charles C. Marboe, Brandon A. Guenthart, John D. O ’Neill, Gordana Vunjak-Novakovic, Matthew Bacchetta Source Type: research