Multiple Criteria Decision Analysis for HTA across four EU Member States: Piloting the Advance Value Framework

Publication date: Available online 15 October 2019Source: Social Science & MedicineAuthor(s): A. Angelis, M. Linch, G. Montibeller, T. Molina Lopez, A. Zawada, K. Orzel, F. Arickx, J. Espin, P. KanavosAbstractMultiple Criteria Decision Analysis (MCDA) has emerged as a likely methodology for Health Technology Assessment (HTA). However limited empirical evidence is available on its use by decision-makers and only as part of single-setting exercises, without cross-county studies available. This pilot study applies the Advance Value Framework (AVF), an MCDA methodology for HTA based on multi-attribute value theory, through a series of case studies with decision-makers in four countries, to explore its feasibility and compare their value preferences and results. The AVF was applied in the evaluation of three drugs for metastatic, castrate resistant, prostate cancer (abiraterone, cabazitaxel and enzalutamide in the post-chemotherapy indication). Decision conferences were organised in four European countries in collaboration with their HTA or health insurance organisations by engaging relevant assessors and experts: Sweden (TLV), Andalusia/Spain (AETSA), Poland (AOTMiT) and Belgium (INAMI-RIZIV). Participant value preferences, including performance scoring and criteria weighting, were elicited through a facilitated decision-analysis modelling approach using the MACBETH technique.Between 6 and 11 criteria were included in the value model of each country, allocated across four criteri...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research