Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery

Prior work has established that that an acute ethanol challenge that mimics high intensity alcohol consumption increased IL-6 and suppressed of IL-1 β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments Sprague-Dawley rats to further extend these results across time course (from 45 min to 6 h after ethanol), sex, and central versus peripheral expression. Furthermore, these data show that cannulati on surgery may selectively modify the central neuroimmune response to ethanol.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research