Potential immunotherapy for Alzheimer disease and age-related dementia.

Potential immunotherapy for Alzheimer disease and age-related dementia. Dialogues Clin Neurosci. 2019 Mar;21(1):21-25 Authors: Schwartz M, Arad M, Ben-Yehuda H Abstract Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD. PMID: 31607777 [PubMed - in process]
Source: Dialogues in Clinical Neuroscience - Category: Neuroscience Tags: Dialogues Clin Neurosci Source Type: research

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