Head-to-head comparison of tau positron emission tomography tracers [ 18 F]flortaucipir and [ 18 F]RO948

Conclusion[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral “off-target” binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands.

http://link.springer.com/10.1007/s00259-019-04496-0

Source: European Journal of Nuclear Medicine and Molecular Imaging - October 13, 2019 Category: Nuclear Medicine Source Type: research