Cancers, Vol. 11, Pages 1550: Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

In conclusion, spironolactone is a safe candidate drug that exerts anti-cancer effects in combination with non-DNA-damaging drugs, such as gemcitabine and osimertinib, most likely through the suppression of survivin.

Source: Cancers - October 13, 2019 Category: Cancer & Oncology Authors: Tomomi Sanomachi Shuhei Suzuki Keita Togashi Asuka Sugai Shizuka Seino Masashi Okada Takashi Yoshioka Chifumi Kitanaka Masahiro Yamamoto Tags: Article Source Type: research