Update in Antibiotic Therapy in Intensive Care Unit Report from the 2019 Nimes International Symposium

Publication date: Available online 10 October 2019Source: Anaesthesia Critical Care & Pain MedicineAuthor(s): Marc Leone, Jason A. Roberts, Matteo Bassetti, Adrien Bouglé, Jean-Philippe Lavigne, Matthieu Legrand, Michael Neely, José-Artur Paiva, Didier Payen, Jordi Rello, Claire Roger, Fredrik Sjövall, Boris JungAbstractThe 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research