Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc5/6.

In conclusion, in contrast to previous observations that tumor HBx variants lack transcriptional activity, we showed here that HBx variants have retained their ability to counteract Smc5/6 and thus to activate cccDNA transcription although they tend to lose antiproliferative activity.
PMID: 31600532 [PubMed - as supplied by publisher]

Source: Antiviral Research - October 6, 2019 Category: Virology Authors: Rivière L, Quioc-Salomon B, Fallot G, Halgand B, Féray C, Buendia MA, Neuveut C Tags: Antiviral Res Source Type: research