Microsatellite instability in young patients with mucinous colorectal cancers & #8211; characterization using molecular testing, immunohistochemistry, and histological features

CONCLUSION: The detection of defective mismatch repair (MMR) proteins using IHC for MLH1, MSH2, and MSH6 and molecular testing using BAT26 and NR24 appears to be a good protocol to detect CRCs with MSI. Histology could be useful in identifying cases that require screening for presence of MMR protein defects.

Source: Indian Journal of Cancer - October 10, 2019 Category: Cancer & Oncology Authors: Nitty Skariah Mathews Dipti Masih Rohin Mittal Benjamin Perakath Dhananjayan Sakthi Grace Rebekah Rekha Pai Anna B Pulimood Source Type: research