Evaluation of transmission potential and pathobiological characteristics of mallard originated Avian orthoavulavirus 1 (sub-genotype VII.2) in commercial broilers

Publication date: Available online 8 October 2019Source: Microbial PathogenesisAuthor(s): Momena Habib, Tahir Yaqub, Aziz-ul-Rahman, Tayyebah Sohail, Muhammad Shahbaz, Wasim Shehzad, Muhammad Munir, Muhammad Zubair ShabbirAbstractNewcastle disease (ND), caused by Avian orthoavulavirus 1 (AOAV-1), affects multiple avian species around the globe. Frequent disease outbreaks are not uncommon even in vaccinates despite routine vaccination and, in this regards, viruses of diverse genotypes originating from natural reservoirs (migratory waterfowls) play an important role in a disease endemic setting. Though genomic characterization of waterfowl originated viruses has been will-elucidated previously, there is a paucity of data on clinico-pathological assessment of mallard-originated sub-genotype VII.2 in commercial chickens. Hence, the current study was designed to evaluate its transmission potential, tissue tropism and micro- and macroscopic lesions in commercial broilers. Based on complete genome and complete F gene, phylogenetic analysis clustered the study isolate within genotype VII and sub-genotype VII.2 in close association with those reported previously from multiple avian species worldwide. The study strain was found to be velogenic on the basis of typical residue pattern in the F-protein cleavage site (112R-RQ-K-R↓F117), sever disease induction in chicken, tissue tropism and subsequent clinico-pathological characteristics. Giving a clear evidence of horizontal transmis...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

Related Links:

[CAJ News] Kinshasa -THE death toll in the measles outbreak afflicting the Democratic Republic of Congo (DRC) has risen to 4 723.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This article updates our laboratory's systematic search for antigens using bioinformatics tools to clarify the Mtb H37Rv Rv3632 protein's topology and location. This article reports a C-terminal region consisting of peptides 39255 and 39256 (81Thr-Arg114) having high specific binding regarding two infection-related cell lines (A549 and U937); they inhibited mycobacterial entry to U937 cells in a concentration-dependent manner. Rv3632 forms part of the mycobacterial cell envelope, formed by six linear synthetic peptides. Circular dichroism enabled determining the protein's secondary structure. It was also found that peptide...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
[Nation] Kenya is on course in the immunisation of 800,000 girls against cervical cancer, Health Cabinet Secretary Sicily Kariuki has said, and allayed fears about the safety of the vaccine.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(University of Maryland) In the first study of public health-related Facebook advertising, newly published in the journal Vaccine, researchers at the University of Maryland, the George Washington University and Johns Hopkins University show that a small group of anti-vaccine ad buyers has successfully leveraged Facebook to reach targeted audiences and that the social media platform's efforts to improve transparency have actually led to the removal of ads promoting vaccination and communicating scientific findings.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionThe combined use of Echinacea with Azithromycin produced favorable outcome than Azithromycin alone in pediatric patients with recurrent tonsillitis.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Chinese health officials say the risk of an outbreak of pneumonic plague is minimal after two new cases were confirmed this week in Beijing, the official China Daily said on Thursday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: January 2020Source: Molecular Immunology, Volume 117Author(s): Dejian Liu, Huijun Zheng, Yaqian Li, Peng Zhou, Hui Jin, Rui LuoAbstractJanus kinase 1 (JAK1) is a member of JAK family of non-receptor protein tyrosine kinases that plays critical roles in transducing cytokine signals via JAK-signal transducer and activator of transcription (STAT) signaling pathway. The importance of JAK1 in innate immunity has been well-studied in mammals and fish, yet in avian remains largely unknown. Here, we cloned the full-length of the duck JAK1 (duJAK1) gene for the first time. DuJAK1 encoded a protein of 1152 amino ac...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane CrottySummaryThe first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we ...
Source: Cell Reports - Category: Cytology Source Type: research
Volume 47, Issue 1, December 2019, Page 4182-4193 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
Publication date: April 2020Source: Food Control, Volume 110Author(s): Naiqing Lin, Kevin R. RobertsAbstractReports from the Center for Control Disease and Prevention suggest that approximately 61% of foodborne illnesses were attributed to improper food handling and is the leading cause of outbreaks in the foodservice industry. However, even when employees are trained in food safety, knowledge does not translate into improved practices on the job. Several meta-analyses have suggested the importance of using injunctive norms to predict individual behavior in both social psychology and management journals. Therefore, the pur...
Source: Food Control - Category: Food Science Source Type: research
More News: Bird Flu | Endemics | Epidemiology | Genetics | Infectious Diseases | Outbreaks | Study | Tonsillitis | Vaccines