CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma [Cell Biology]

Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expressed in osteosarcoma and undergoes nuclear-cytoplasmic...

http://www.pnas.org/content/116/41/20511.short?rss=1

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Qian Ran, Feng Jin, Yang Xiang, Lixin Xiang, Qiushi Wang, Fengjie Li, Li Chen, Yuan Zhang, Chun Wu, Luping Zhou, Yanni Xiao, Lili Chen, Jiang Wu, Jiang F. Zhong, Shengwen Calvin Li, Zhongjun Li Tags: Biological Sciences Source Type: research