Cell models of lipid-rich {alpha}-synuclein aggregation validate known modifiers of {alpha}-synuclein biology and identify stearoyl-CoA desaturase [Neuroscience]

Microscopy of Lewy bodies in Parkinson’s disease (PD) suggests they are not solely filamentous deposits of α-synuclein (αS) but also contain vesicles and other membranous material. We previously reported the existence of native αS tetramers/multimers and described engineered mutations of the αS KTKEGV repeat motifs that abrogate the multimers. The...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Thibaut Imberdis, Joseph Negri, Nagendran Ramalingam, Elizabeth Terry-Kantor, Gary P. H. Ho, Saranna Fanning, Georgia Stirtz, Tae-Eun Kim, Oren A. Levy, Tracy L. Young-Pearse, Dennis Selkoe, Ulf Dettmer Tags: PNAS Plus Source Type: research