The End Of Guinea Worm Was Just Around the Corner. Not Anymore

The World Health Organization had hoped to eradicate the painful parasite by 2020. That deadline just got moved a decade into the future. And dogs are part of the problem.(Image credit: Sally Deng for NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Publication date: Available online 21 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Wesley L. Fotoran, Thomas Müntefering, Nicole Kleiber, Beatriz N.M. Miranda, Eva Liebau, Darrell J. Irvine, Gerhard WunderlichAbstractLipid particles for drug delivery can be modified to create multilayer vesicles with higher stability and improved cargo interaction. Here, we used lipids capable of forming hydrogen bonds instead of covalent bonds and designed stable vesicles-inside-vesicles with a high capacity of entrapping antimalarial drugs such as chloroquine (hydrophilic) and Artemisinin (lipophi...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Natália F. Martins Root-knot nematodes (RKN), from the Meloidogyne genus, have a worldwide distribution and cause severe economic damage to many life-sustaining crops. Because of their lack of specificity and danger to the environment, most chemical nematicides have been banned from use. Thus, there is a great need for new and safe compounds to control RKN. Such research involves identifying beforehand the nematode proteins essential to the invasion. Since G protein-coupled receptors GPCRs are the target of a large number of drugs, we have focused our research on the identification of putative nematode GPCRs ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: Naturally acquired sexual stage immunity, as detected by antibodies to Pfs230 and Pfs48/45, was present in most studies analyzed. Significant between-study heterogeneity was seen, and methodological factors were a major contributor to this, and prevented further analysis of epidemiological and biological factors. This demonstrates a need for standardized protocols for conducting and reporting seroepidemiological analyses.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractA major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method for drug target deconvolution inPlasmodium falciparum is in vitro evolution of compound-resistant parasites followed by whole-genome scans. Several of the most promising antimalarial drug targets, such as translation elongation factor 2 (eEF2) and phenylalanine tRNA synthetase (PheRS), have been identified or confirmed using this method. One drawback of this method is that if a mu...
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
Publication date: December 2019Source: Molecular Immunology, Volume 116Author(s): Bijara Devi Sanasam, Sanjeev KumarAbstractMalaria caused by Plasmodium falciparum is the most deadly and a major health issue worldwide. In spite of several control programs, there hasn’t been much improvement in keeping the disease under control. The appearance of drug resistant strains of Plasmodium in addition to insecticide resistance of the Anopheles vector has been a hurdle. Therefore, it is highly desirable to identify new potential candidates that can be targeted for therapeutic intervention. The present study identifies AMR1, a...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
This week's case was generously donated by Professor Agnes Kurniawan from the University of Indonesia. The following motile structure was reported to emerge from the anus of a man from rural Indonesia. He had no other gastrointestinal symptoms.You can see its subtle movement here:This structure was expressed from the submitted object:Identification?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
In conclusion, the present work adds new morphological and molecular information, emphasizing the importance of adopting integrative taxonomic approaches in studies of Acanthocephala.Graphical abstract
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
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Source: Insect Science - Category: Biology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 19 October 2019Source: Veterinary ParasitologyAuthor(s): Rogério F. de Jesus, Waléria Borges-Silva, Taynar L. Bezerra, Leane Q. Gondim, Rosângela S. Uzêda, Luís F.P. GondimAbstractSarcocystis neurona is the major cause of the equine protozoal myeloencephalitis (EPM) in the Americas and has opossums of the genus Didelphis as definitive hosts. Most isolates of Sarcocystis sp. shed by opossums in Brazil differ genetically from the known species of Sarcocystis. These Brazilian isolates behave similarly as Sarcocystis falcatula, which causes sarcocystosis in bi...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Authors: Ben-Harari RR Abstract Introduction: Infection with Toxoplasma gondii (T. gondii) causes the disease toxoplasmosis in humans and animals. Oral transmission alone may not explain the widespread distribution of this parasite over large species of host animals and geographic areas. Areas covered: Limited studies indicate the potential role of ticks in the distribution of T. gondii. The possibility of transmission of T. gondii has been demonstrated in Dermacentor variabilis, Dermacentor andersoni, Amblyomma americanum, Dermacentor reticulatus, Ixodes ricinus, Ixodes amblyomma, Amblyomma cajennense, Ornithodoru...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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