Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines

Conclusion: S. kronenburgii might be a promising natural source for cancer therapy. Further experiments need to be done in vivo to understand of the anticancer effects of this plant.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research

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Cancer of the uterine cervix is among the most preventable human malignancies, yet it remains a leading cause of death among women worldwide, accounting for more than 300  000 deaths annually. Well on its way to elimination in the global north, cervical cancer mostly affects women living in low- or middle-income countries (LMICs), where limited access to vaccination, screening, and therapy have made it overwhelmingly a disease of women who are poor and lack access to health care. Nowhere is this more evident than in sub-Saharan Africa, where HIV is endemic and where cervical cancer has surpassed breast cancer as the most...
Source: JAMA - Category: General Medicine Source Type: research
TIME held its first TIME 100 Health Summit on Thursday aiming to define — and shape — the future of health care. The Summit, which is an offshoot of the magazine’s annual TIME 100 list of influential people, featured scientists, politicians and entertainers, such as former President Bill Clinton, former Vice President Al Gore, NIH Director Dr. Francis Collins, actress Selma Blair, NBA commissioner Adam Silver, comedian Tig Notaro and former Planned Parenthood President Dr. Leana Wen. The day included a range of interviews, panels and performances. Here are the biggest moments from the Summit. Former Vice ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Comedy HealthSummit19 onetime Source Type: news
In this study, we reported the biomedical potentials of 2-hydoxy 4-methylbenzaldehyde (2H4MB) from D. arayalpathra. The compound 2H4MB was isolated from fleshy root barks of the plants using steam-hydro distillation extraction method and quantified using HPLC analysis, which yielded 6.5 ± 0.8 μg g−1 of purified compound. Further, the antioxidant and anticancer effects in vitro were studied in detail using MDA-MB-231 cells by cell-based assays. 2H4MB was observed to display the features such as generation of reactive oxygen species (ROS), improved cytotoxicity, loss of mitochondrial membrane (&Delt...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
nka Bijen Kivcak Judit Hohmann Multistep chromatographic separations of the chloroform extract of the Turkish endemic plant Psephellus pyrrhoblepharus (Boiss.) Wagenitz (syn. Centaurea pyrrhoblephara Boiss.) resulted in the isolation of six guaianolid-type sesquiterpenes, chlorojanerin (1), 19-deoxychlorojanerin (2), 15-hydroxyjanerin (3), aguerin B (4), cynaropicrin (5), eleganin (6); three flavonoids, apigenin, 6-methoxyluteolin and jaceosidine; two glycosides, benzyl-1-O-β-d-glucoside and 3(Z)-hexenyl-1-O-β-d-glucoside; and the coumarin scopoletin. The structures were established by the interpr...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion: In this study, no correlation between EBV and thyroid diseases was found in a cohort from southern China. Introduction Epstein-Barr virus (EBV) is a well-known human tumor virus with a very high prevalence in the population, especially for children and youth. EBV serum (IgG) is positive in an estimated 95% of the world's population (1). EBV infection is associated with epithelial and lymphoid malignancies, including nasopharyngeal carcinoma (NPC), gastric cancer, Hodgkin's lymphoma and Burkitt's lymphoma (2, 3). Although EBV has B-lymphocyte tropism, it can also infect T lymphocy...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, we found that the activities of alkaline phosphatase (ALP) and mineralized nodules in MC3T3-E1 cells were both significantly increased after treatment with AG (5, 10, and 20 μM). Meanwhile, the mRNA and protein levels of osteoblastic marker genes in MC3T3-E1 cells after AG treatment were markedly increased compared with a control group. In addition, the levels of BMP-2, p-Smad1/5/9, and Runx2 were significantly elevated in AG-treated MC3T3-E1 cells. Moreover, we found that the protein levels of Erk1/2, p-Erk1/2, p38, p-p38, and p-JNK were also significantly increased in AG-treated MC3T3-E1 cells compared ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study was geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of ethyl acetate, methanol, and water extracts of Sideritis ozturkii Aytaç &Aksoy. The phytochemical profiles of the studied extracts were characterised by HPLC-MS/MS. The methanol extract, rich in phenolics (78.04 mg gallic acid equivalent/g), exhibited the strongest antioxidant activities. However, the ethyl acetate extract was the most active extract in the enzyme inhibitory assays. The water extract of S. ozturkii (1 mg/ml, 48 h incubation) slightly inhibited (22%) growth of huma...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
In conclusion, this Research Topic includes a wide range of interdisciplinary research work contributing to the ultimate goals of augmenting the existing knowledge and fostering the scientific field of ethnopharmacology in Central and Eastern Europe, as well as globally. This research topic successfully gathered comprehensive interdisciplinary information in the field of ethnopharmacology from the field surveys to standardization and elucidation of molecular mechanisms of action of natural products. Moreover, with consideration of the existing challenges in the field of drug discovery form medicinal plants, this research t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Michael G. Knott, Jo-Anne de la Mare, Adrienne L. Edkins, Angel Zhang, Martin J. Stillman, John J. Bolton, Edith M. Antunes, Denzil R. BeukesAbstractThe endemic South African red seaweed Plocamium maxillosum (Poiret) Lamouroux produces two unusual isomeric dichlorinated cyclohexenone monoterpenes, plaxenone A and B (1 and 2). The structures of the isolated compounds were determined from spectroscopic data and their absolute configuration was determined by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 inhibit th...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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