Genes, Vol. 10, Pages 716: Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia
Genes, Vol. 10, Pages 716: Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia
Genes doi: 10.3390/genes10090716
Authors:
Ricardo De la Rosa
Vanessa Villegas-Ruíz
Marcela Concepción Caballero-Palacios
Eleazar Israel Pérez-López
Chiharu Murata
Martha Zapata-Tarres
Rocio Cárdenas-Cardos
Rogelio Paredes-Aguilera
Roberto Rivera-Luna
Sergio Juárez-Méndez
B-cell acute lymphoblastic leukemia is the most commonly diagnosed childhood malignancy worldwide; more than 50% of these cases are diagnosed in Mexico. Although the five-year survival rate is >80%, 30% of patients experience relapse with poor prognosis. Cancer-associated gene expression profiles have been identified in several malignancies, and some transcripts have been used to predict disease prognosis. The human transcriptome is incompletely elucidated; moreover, more than 80% of transcripts can be processed via alternative splicing (AS), which increases transcript and protein diversity. The human transcriptome is divided; coding RNA accounts for ~2%, and the remaining 98% is noncoding RNA. Noncoding RNA can undergo AS, promoting the diversity of noncoding transcripts. We designed specific primers to amplify previously reported alternative transcript variants of ZNF695 and showed that six ZNF695 transcript variants are co-expressed in cancer cell lines. The amplicons were sequenced and identified. Additionally, we analyzed the expression of these ...
Source: Genes - Category: Genetics & Stem Cells Authors: Ricardo De la Rosa Vanessa Villegas-Ru íz Marcela Concepci ón Caballero-Palacios Eleazar Israel P érez-López Chiharu Murata Martha Zapata-Tarres Rocio C árdenas-Cardos Rogelio Paredes-Aguilera Roberto Rivera-Luna Sergio Ju árez-Méndez Tags: Article Source Type: research
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