Dynamic bonds and their roles in mechanosensing.

Dynamic bonds and their roles in mechanosensing.
Curr Opin Chem Biol. 2019 Sep 26;53:88-97
Authors: Zhu C, Chen Y, Ju LA
Abstract
Mechanical forces are ubiquitous in a cell's internal structure and external environment. Mechanosensing is the process that the cell employs to sense its mechanical environment. In receptor-mediated mechanosensing, cell surface receptors interact with immobilized ligands to provide a specific way to receive extracellular force signals to targeted force-transmitting, force-transducing and force-supporting structures inside the cell. Conversely, forces generated endogenously by the cell can be transmitted via cytoplasmic protein-protein interactions and regulate cell surface receptor activities in an 'inside-out' manner. Dynamic force spectroscopy analyzes these interactions on and inside cells to reveal various dynamic bonds. What is more, by integrating analysis of molecular interactions with that of cell signaling events involved in force-sensing and force-responding processes, one can investigate how dynamic bonds regulate the reception, transmission and transduction of mechanical signals.
PMID: 31563813 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - September 25, 2019 Category: Biochemistry Authors: Zhu C, Chen Y, Ju LA Tags: Curr Opin Chem Biol Source Type: research