1133PSystemic bevacizumab for the treatment of recurrent respiratory papillomatosis: A retrospective analysis from an academic tertiary care center
ConclusionsSystemic bevacizumab appears to be a safe and well tolerated treatment option for patients with severe RRP. It demonstrates promising efficacy on symptoms including voice quality and improved breathing as well as decreased requirement for surgical therapy.Legal entity responsible for the studyThe author.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher]
Publication date: Available online 11 December 2019Source: Life SciencesAuthor(s): Qingting Wang, Wenhua Shi, Qianqian Zhang, Wei Feng, Jian Wang, Cui Zhai, Xin Yan, Manxiang LiAbstractAimsIt has been shown that up-regulation of E3 ubiquitin ligase seven-in-absentia-homolog 2 (Siah2) and activation of Hippo signaling pathway effector yes-associated protein (YAP) are involved in the development of pulmonary arterial hypertension (PAH). However, it is still unclear whether Siah2 activates YAP in MCT-induced PAH rat model.Main methodsIntraperitoneal injection of monocrotaline (MCT) was used to induce PAH rat models. The right...
In this study, N-methylated peptide inhibitors F-N(Me)H-L, V-N(Me)F-R and R-N(Me)V-Y were synthesized against ACE, NEP and APN respectively, using their respective physiological substrates. F-N(Me)H-L inhibited ACE activity with an IC50 of 83 nmol/L, V-N(Me)F-R inhibited NEP activity with an IC50 of 1.173 μmol/L and R-N(Me)V-Y inhibited APN activity with an IC50 of 3.94 nmol/L respectively. Further, the anti-hypertensive effect of N-methylated peptides was evaluated using rat model of dexamethasone-induced hypertension. Individual peptides and their cocktail treatment were started from day 6 of the ...
Conditions: Metastatic Colorectal Cancer; RAS Mutation Interventions: Drug: sintilimab injection; Drug: XELOX + Bevacizumab Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting
Condition: Carcinoma, Non-Small-Cell Lung Interventions: Drug: Atezolizumab; Drug: Placebo; Drug: Bevacizumab; Drug: Paclitaxel; Drug: Pemetrexed; Drug: Carboplatin Sponsor: Hoffmann-La Roche Not yet recruiting
Conditions: Pulmonary Artery Hypertension; Right Ventricular Dysfunction Intervention: Procedure: Temporary right ventricular pacing Sponsor: University of California, San Francisco Not yet recruiting
Conditions: Chronic Obstructive Pulmonary Disease (COPD; Arterial Hypertension; Diabetes Mellitus Interventions: Other: ANM; Other: Placebo Sponsor: Andalusian School of Public Health Recruiting
Publication date: Available online 11 December 2019Source: Pregnancy HypertensionAuthor(s): Anisha R. Bouter, Johannes J. DuvekotAbstractBackgroundIn 2018/2013 both ISSHP and ACOG revised their original statements and postulated new criteria for preeclampsia with and without severe features. Most importantly, preeclampsia can now also be established in the absence of proteinuria when other specific symptoms are present.ObjectiveWhat is the clinical impact of the use of three different new definitions for the diagnosis of preeclampsia?Study designRetrospective cohort study of all pregnant women who gave birth in the Erasmus...
Does the thrombopoietin receptor agonist romiplostim expedite correction of thrombocytopenia caused by chemotherapy?Journal of Clinical Oncology
HIGH blood pressure is prevalent in the UK, with more than one in four people living with it. The condition is often dubbed the “silent killer” because symptoms rarely show up until it is serious so it is important to take steps to keep your blood pressure in check. Diet plays a key role in controlling blood pressure, with certain foods shown to provide particular blood pressure-lowering benefits, including a breakfast s taple.