Observation versus Immediate Re-induction for Acute Myeloid Leukemia Patients with Indeterminate Day 14 Bone Marrow Results

The benefit of immediate re-induction chemotherapy in patients with indeterminate day 14 bone marrow results ( ≤ 20% cellularity and 5%-20% blasts) remains unclear. Our retrospective analysis compared 25 patients receiving immediate re-induction to 25 patients undergoing observation for indeterminate day 14 results. We did not find a statistically significant difference in overall response rates, or surviv al outcome measures between both groups. Our findings question the utility of immediate re-induction chemotherapy and raise concern for over treatment in this patient population.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research