Fluorescent probes for monitoring regulated secretion.

Fluorescent probes for monitoring regulated secretion.
Curr Opin Chem Biol. 2013 May 24;
Authors: Li WH, Li D
Abstract
Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.
PMID: 23711436 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - May 24, 2013 Category: Biochemistry Authors: Li WH, Li D Tags: Curr Opin Chem Biol Source Type: research