Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response [Cell Biology]

High-risk human papillomaviruses (HR-HPVs) promote cervical cancer as well as a subset of anogenital and head and neck cancers. Due to their limited coding capacity, HPVs hijack the host cell’s DNA replication and repair machineries to replicate their own genomes. How this host–pathogen interaction contributes to genomic instability is unknown....

Source: Proceedings of the National Academy of Sciences - September 23, 2019 Category: Science Authors: Justine Sitz, Sophie Anne Blanchet, Steven F. Gameiro, Elise Biquand, Tia M. Morgan, Maxime Galloy, Julien Dessapt, Elise G. Lavoie, Andreanne Blondeau, Brandon C. Smith, Joe S. Mymryk, Cary A. Moody, Amelie Fradet–Turcotte Tags: PNAS Plus Source Type: research