Arrhythmogenic propensity of the fibrotic substrate after atrial fibrillation ablation: a longitudinal study using magnetic resonance imaging-based atrial models

ConclusionRecurrent AF after PVI in the fibrotic atria may be attributable to both preserved RDs that sustain AF pre- and post-ablation, and the emergence of new RDs following ablation. The same levels of fibrosis entropy and density underlie the pro-RD propensity in both pre- and post-ablation substrates.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Condition:   Atrial Fibrillation Interventions:   Diagnostic Test: High density electrophysiological mapping;   Diagnostic Test: Cardiac Magnetic Resonance Imaging Sponsor:   Oxford University Hospitals NHS Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Atrial fibrillation (AF) is associated with changes in left atrial (LA) anatomy, function and substrate [1,2]. LA volumes are related to the success of AF catheter ablation, but the relation to other functional and structural parameters are less well understood. Additionally, ablation for AF could also cause LA functional impairment. Therefore, assessing these changes with cardiac magnetic resonance imaging (CMRi) could help us predict outcomes and improve patient selection. Analyses like these are important additions to the literature investigating the role of pre-procedural imaging.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Condition:   Atrial Fibrillation Interventions:   Diagnostic Test: High density electrophysiological mapping;   Diagnostic Test: Cardiac Magnetic Resonance Imaging Sponsor:   Oxford University Hospitals NHS Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionBased on serial MRI, atrial ablation lesions are often fully mature before the typical 90 ‐day blanking period, which could support more timely clinical decision making for arrhythmia recurrence.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractPurpose of ReviewAtrioesophageal fistula (AEF) is a rare yet catastrophic complication of atrial fibrillation (AF) ablation. Limited data exists on measures to prevent AEF. This review focuses on AF ablation approaches, esophageal protective strategies, and imaging modalities that can be utilized to reduce the risk of AEF.Recent FindingsAEF has been reported to occur in less than 0.1% of AF ablation cases. Left untreated, it is associated with 100% mortality. Diagnosing AEF requires a high index of suspicion as symptoms are usually nonspecific. Several AF ablation techniques might reduce the risk of esophageal ther...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
ConclusionsPulmonary vein isolation is the treatment of choice for symptomatic patients with paroxysmal and persistent drug-refractory AF. The reconnection of previously isolated pulmonary veins remains the major cause of AF recurrence. Novel ablation tools, such as balloon technologies or alternative energy sources, might help to overcome this limitation. Patients with non-paroxysmal AF and with AF recurrence might benefit from alternative ablation strategies. However, further studies are warranted to further improve our knowledge of the underlying mechanisms of AF and to obtain long-term clinical outcomes on new ablation techniques.
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
CONCLUSIONS: This is the first case with retinal aura phenomena meeting International Classification of Headache Disorders diagnostic criteria for retinal migraine, suggesting that this rare migraine variant can be triggered by TSC. PMID: 31889309 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
ConclusionsIntravenous thrombolytic therapy with recombinant tissue plasminogen activator after reversal of dabigatran with idarucizumab may be safe and feasible in patients with acute ischemic stroke with lacunar infarct. Furthermore, intravenous thrombolytic therapy with recombinant tissue plasminogen activator could be used in patients in emergency settings until just before the end of the recommended time limit within which it needs to be administered because of the immediate effect of idarucizumab.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusion: NF formation post ‐ablation of AF is a novel marker of long‐term procedural outcome. Extensive NF is associated with significantly higher risk of atrial arrhythmia recurrence.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
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