How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer

Publication date: Available online 22 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marie Lange, Hélène Castel, Johan Le Fel, Laure Tron, Didier Maillet, Myriam Bernaudin, Omar Touzani, Joy Perrier, Mathieu Boone, Idlir Licaj, Bénédicte Giffard, Martine Dubois, Olivier Rigal, Thomas Durand, Catherine Belin, Damien Ricard, Rozenn Le Gal, Véronique Pancré, Isabelle Hardy-Léger, Florence JolyAbstractA number of neurotoxicity associated with oncological treatments has been reported in non-central nervous system cancers.An expert group presents the state of the art and a guide to help the choice of appropriated tools to assess patient cognition in studies on oncology and neurobehavior in animal models. In addition, current cognitive rehabilitation programs currently under evaluation are also discussed.Cognitive assessments in oncology depend on the research question, study design, cognitive domains, patients’ characteristics, psychometric properties of the tests, and whether the tests are supervised or not by a neuropsychologist. Batteries of electronic tests can be proposed, but several of them are characterized by weak psychometric developments. In order to improve the comprehension on the impact of cancer treatments on cognition, new animal models are in development, and would in the future include non-human primate models.By bringing together the skills and practices of oncologists, neurologists, neuropsychologists, neuroscientists, we propose a...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research