Plasma-free amino acid profiling of nasal polyposis patients.

Plasma-free amino acid profiling of nasal polyposis patients. Comb Chem High Throughput Screen. 2019 Sep 20;: Authors: Celik M, Şen A, Koyuncu İ, Gönel A Abstract AIM AND OBJECTIVE: Mechanisms in etiopathogenesis of nasal polyposis; particularly, it is not clear whether the amino acids contribute in a causal way to the development of the disease. The aim of this study was to determine the plasma-free amino acid profile in patients with nasal polyposis and to compare the results with the healthy control group. MATERIALS AND METHODS: This is a prospective controlled study of the Ear-Nose-Throat Department of the Our University Faculty of Medicine between April 2017 and April 2018. The study included 25 patients with nasal polyposis and 20 healthy control groups. Plasma-free amino acid profiles levels were studied in serum samples taken from the patient group and the healthy control group. RESULTS: In patients with nasal polyposis; 2-Methyl histidine (2-MHIS), arginine (arg), asparagine (asn), citrulline (cit), cystine (cys), glutamic acid (glu), serine (ser), taurine (tau), tryptophan (trp) , lysine (Lys), ornithine, homocitrulline, norvaline, argininosuccinic acid plasma concentrations were significantly higher than healthy control group (p
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

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