Current prevention and potential treatment options for dengue infection.

Current prevention and potential treatment options for dengue infection. J Pharm Pharm Sci. 2019;22(1):440-456 Authors: Jasamai M, Yap WB, Sakulpanich A, Jaleel A Abstract Currently, treatments for dengue infection are only symptomatic as no antiviral agents nor vaccines are available to combat this virus. Despite challenges faced by researchers, many efforts are ongoing to reduce cases of dengue infection either by targeting the vector or the virus. Vector population is monitored and reduced by using mechanical, chemical and biological controls. Chemical control is achieved either by using synthetic or natural insecticides where the latter is more preferable. In biological control, bacteria, fungi and larvivorous fish are utilised to reduce the vector population. Moreover, genes of mosquitoes are also explored to produce progenies which are sterile with low survival ability. Vaccines are among the most effective ways to prevent viral infection. Various approaches have been used and are still being explored towards producing vaccines for dengue. These include live attenuated, inactivated, recombinant subunit, nucleic acid and virus-like particles vaccines. The aim is to produce a vaccine which can target all the four serotypes of the virus. Monoclonal antibodies are widely researched on to equip the host defense mechanism against the dengue virus. Deeper understanding of the virus replication cycle warrants the development of antiviral agents which targe...
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research

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Condition:   Dengue Interventions:   Biological: Tetravalent live attenuated dengue vaccine admixture TV005;   Biological: Placebo Sponsors:   National Taiwan University Hospital;   Centers for Disease Control, Taiwan Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This Viewpoint uses experience with rotavirus vaccine –induced intussusception and dengue virus vaccine–induced shock syndrome to discuss issues of disease prevalence and severity underlying recommendations the vaccines be used widely, and it reviews the systems in place to monitor vaccine safety that broadly favor vaccine benefits over risks to in dividuals and society.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Abstract Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophylaxis are only available for several flaviviruses such as Yellow Fever virus, Tick-borne Encephalitis Virus, Dengue Virus and Japanese Encephalitis Virus and there is no antiflaviviral agent being marketed. This review discusses the flavivirus genome, replication cycle, epidemiology, clinical presentation and pat...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
Source: World Health Organization, Pan American Health Organization (PAHO). Published: 10/9/2019. This 60-page manual provides technical guidelines for the strategic use of indoor residual spraying for Aedes aegypti mosquito control (IRS-Aedes) in urban areas, and compiles and standardizes the criteria, instruments, technical parameters, and equipment, as well as the application technique, for strategic integration of IRS-Aedes in Aedes aegypti control programs. Given the absence of a specific treatment and vaccines against dengue, chikungunya, and Zika, and the limitations of current vector control strategies, the World ...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Abstract 14-3-3 protein family members facilitate the translocation of RIG-I-like receptors (RLRs) to organelles that mediate downstream RLR signaling, leading to interferon production. 14-3-3ϵ promotes the cytosolic-to-mitochondrial translocation of RIG-I, while 14-3-3η facilitates MDA5 translocation to mitochondria. We show that the NS3 protein of Zika virus (ZIKV) antagonizes antiviral gene induction by RIG-I and MDA5 by binding to and sequestering the scaffold proteins 14-3-3ϵ and 14-3-3η. 14-3-3-binding is mediated by a negatively charged RLDP motif in NS3 that is conserved in ZIKV strains of Africa...
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research
Authors: Rastogi N, Nayan A, Sethi P, Nischal N, Brijwal M, Kumar A, Wig N Abstract Dengue is the most common arboviral disease affecting many countries worldwide. With endemicity of the disease and huge burden, atypical clinical presentations occur posing high diagnostic and therapeutic dilemma. Emerging neurological complications in dengue fever are reported in recent past Acute disseminated encephalomyelitis (ADEM) is an immune mediated acute demyelinating disorder of the central nervous system following recent infection or vaccination and characterized by multifocal white matter involvement. Early suspicion and...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Condition:   Dengue Fever Intervention:   Sponsor:   Sanofi Pasteur, a Sanofi Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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