Changes in transporters and metabolizing enzymes in the livers of rats with bile duct ligation.

CONCLUSIONS: This study reports the comprehensive changes of transporters, metabolizing enzymes, nuclear receptors, and ezrin/radixin/moesin proteins in the livers of BDL rats. The expression levels of nuclear receptors and radixin that regulate the transcription and localization of CYP and/or transporters were decreased by BDL. PMID: 31539322 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31539322?dopt=Abstract

Source: J Pharm Pharm Sci - September 22, 2019 Category: Drugs & Pharmacology Authors: Kawase A, Kazaoka A, Yamamoto R, Minakata R, Shimada H, Iwaki M Tags: J Pharm Pharm Sci Source Type: research