Molecules, Vol. 24, Pages 3433: Investigation of 5 ’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Molecules, Vol. 24, Pages 3433: Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents Molecules doi: 10.3390/molecules24193433 Authors: Anastasia L. Khandazhinskaya Elena S. Matyugina Pavel N. Solyev Maggie Wilkinson Karen W. Buckheit Robert W. Buckheit Larisa N. Chernousova Tatiana G. Smirnova Sofya N. Andreevskaya Khalid J. Alzahrani Manal J. Natto Sergey N. Kochetkov Harry P. de Koning Katherine L. Seley-Radtke Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research