Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors.
Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors. Neurochem Res. 2019 Sep 17;: Authors: Wang Y, Liu Q, Xie J, Feng R, Ma F, Wang F, Shen S, Wen T Abstract The hippocampus is critical for memory and emotion and both N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptors are known to contribute for those processes. However, the underlying molecular mechanisms remain poorly understood. We have previously found that mice undergo memory decline upon dcf1 deletion through ES gene knockout. In the present study, a nervous system-specific dcf1 knockout (NKO) mouse was constructed, which was found to present severely damaged neuronal morphology. The damaged neurons caused structural abnormalities in dendritic spines and decreased synaptic density. Decreases in hippocampal NMDA and AMPA receptors of NKO mice lead to abnormal long term potentiation (LTP) at DG, with significantly decreased performance in the water maze, elevated- plus maze, open field and light and dark test. Investigation into the underlying molecular mechanisms revealed that dendritic cell factor 1 (Dcf1) contributes for memory and emotion by regulating NMDA and AMPA receptors. Our results broaden the understanding of synaptic plasticity's role in cognitive function, thereby expanding its known list of functions. PMID: 31531752 [PubMed - as supplied by publisher]
BACKGROUND: Rates of anxiety and depression are increasing among children and young people. Recent policies have focused on primary prevention of mental disorders in children and young people, with schools at the forefront of implementation. There is limit...
Depression and anxiety are common neuropsychiatric manifestations of Parkinson disease. However, they are often under-recognized because the somatic symptoms of depression often overlap with the motor symptoms of Parkinson disease and there is low self-rep...
ConclusionsU.S. children and adolescents are prescribed benzodiazepines for various mental health and other medical conditions, many lacking evidence of pediatric efficacy. Long-term benzodiazepine treatment, concurrent opioid prescriptions, psychotropic use, and prior substance use disorder diagnoses suggest safety risks among some youth prescribed benzodiazepines.
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Maria Anesti, Natalia Stavropoulou, Korina Atsopardi, Fotini N. Lamari, Nikolaos T. Panagopoulos, Marigoula MargarityAbstractThe aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbra...
We studied the effect of gonadotropin-releasing hormone agonist surfagon (2 μg/kg, once, intraperitoneally) on anxious behavior of adult gonadectomized and non-gonadectomized male rats. It was shown that surfagon significantly increased anxiety of both gonadectomized and non-gonadectomized rats in the open-field test and in elevated plus maze
CONCLUSIONS: This is the largest cohort reported in the literature of patients with frostbite injuries treated with HBOT. Hyperbaric oxygen therapy may show positive impact on the demarcation level of frostbite and, despite the common side effects, it generally causes no long-term sequelae. PMID: 31730511 [PubMed - as supplied by publisher]
ConclusionsCSU has strong negative effects on female sexual function, especially in patients with angioedema. Additional studies on sexual health in patients with CSU are needed and should focus on the impact of effective treatment on sexual functioning.
The basic science underlying biological psychiatry came first from animal models. For example, rodent studies established the pathways through which early-life experience and stress impact brain systems involved in anxiety and depression (1). With the advent of modern neuroimaging it became possible to study these systems as they function in healthy humans and in those with psychiatric disorders (2).
Anxiety disorders, the most prevalent class of pediatric mental disorders, are viewed as conditions of abnormal threat processing. The circuitry engaged by threats in a range of mammalian species encompasses the amygdala and its connections to the ventral prefrontal cortex, insula, and hippocampus. Thus, this circuitry can be targeted in translational research. Cross-species translational research is crucial for psychiatry given the inaccessibility of the human brain to many research techniques.
The research found that the practice changes the way the brain processes fearful memories. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do