Development, characterization and pharmacokinetics of mupirocin-loaded nanostructured lipid carriers (NLCs) for intravascular administration

The objective of this research is to develop and characterize Mupirocin-Loaded Nanostructured Lipid Carriers (M-NLC) for intravascular administration. The MNLC was produced by a combination of high- shear homogenization and high-pressure homogenization of solid (cetyl palmitate) and liquid (caprylic/caprylic acid) biocompatible lipids in 5 different ratios. The mean particle size, polydispersity index (PDI) and the zeta potential (ZP) of the MNLC formulations were between 99.8 and 235 nm, PDI lower than 0.164, ZP from −25.96 to −19.53 and pH ranging from 6.28–6.49. The MNLC formulation also enhances the anti-bacterial activity of mupirocin. All formulation showed sustained drug release and good physical characteristics for three months storage under 25 °C. It also revealed that the MNLC 1 is safe at 250 mg/kg dose in rats. The MNLC 1 also showed a significant increase in plasma concentration in rabbits following IV administration; thus, demonstrating an enhancement on its pharmacokinetic profile as compared to free mupirocin.Graphical Abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Ling-Yuan Guo, Shu-Zhen Yan, Xin Tao, Qing Yang, Qiang Li, Tian-Shu Wang, Shu-Qin Yu, Shuang-Lin ChenAbstractThere is an urgent need for new antibacterial strategies to overcome the emergence of antibiotic resistance. Antibacterial photodynamic therapy (APDT) may be an effective method to deliver photosensitizers for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report that the photosensitizer hypocrellin A (HA) loaded into lipase-sensitive methoxy poly (ethylene glycol)-block-poly(&ep...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
In this study, we investigated the prevalence of the tst gene in clinical isolates of S. aureus. Then, animal experiments were performed to further evaluate the influence of the presence of the tst gene associated Staphylococcus aureus Pathogenicity Island (SaPI) on body weight, serum cytokine concentrations and the bacterial load in different organs. In addition, macrophages were used to analyze the secretion of cytokines in vitro and bacterial survival in the cytoplasm. Finally, pathological analysis was carried out to evaluate organ tissue impairment. The results demonstrated that the prevalence of tst gene was approxim...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
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Source: Shock - Category: Emergency Medicine Tags: Online Articles Source Type: research
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Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 15 October 2019Source: American Journal of Infection ControlAuthor(s): Hiroki Kitagawa, Minako Mori, Seiya Kashiyama, Yayoi Sasabe, Kiyoko Ukon, Naomi Shimokawa, Nobuaki Shime, Hiroki OhgeBackgroundThe hospital environment is an important source of multidrug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA). Here, we evaluated the efficacy of pulsed xenon ultraviolet (PX-UV) disinfection in addition to manual cleaning in a Japanese hospital.MethodsEnvironmental samples were collected from inpatient rooms that had been occupied for at least 48 hours by patients...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
In conclusion, we found greater BMAT is associated with greater loss of trabecular bone at the spine and femoral neck, and greater loss of spine compressive strength, in older women.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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