Anemia in Early Pregnancy May Harm Child Neurodevelopment

WEDNESDAY, Sept. 18, 2019 -- Anemia diagnosed during the first 30 weeks of pregnancy is associated with an increased risk for autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID),...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins, and growth differentiation factors exert inhibitory effects on red cell formation by activating canonical SMAD2/3 pathway signaling. In this Review, we summarize evidence that overactivation of SMAD2/3 signaling pathways in MDSs causes anemia due to impaired erythroid maturation. We also describe the basis for biological activity of activin receptor ligand traps, novel fusion proteins such as ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
How bad of an idea is it to be pregnant with adequate lead coverage during early months of pregnancy? I had a fellow resident who was pregnant who changed her rotations around to avoid any exposure, however it's my understanding that overall the exposure with adequate coverage is ultimately fine. I know most of you are men - not sure if there are any female pain docs who could chime in? Sigh.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
ConclusionThree unhealthy TCM patterns during the preconception period might be risk factors for low fecundity or poor pregnancy outcomes. The TCM preconception pattern identification may provide a convenient and effective way to screen for potential pregnancy risks beyond the NFPC. Further, appropriate interventions based on the TCM preconception health patterns are needed to improve quality in women’s fecundability and birth outcomes.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
We describe recent female sterilization and reversible prescription contraceptive method use by presence of CHD and CHD severity in 2014.MethodsUsing IBM MarketScan Commercial Databases, we included women aged 15–44 years with prescription drug coverage in 2014 who were enrolled ≥11 months annually in employer-sponsored health plans between 2011–2014. CHD, CHD severity, contraceptive methods, and obstetric-gynecology and cardiology provider encounters were identified using billing codes. We used log-binomial regression to calculate adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: February 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 2Author(s): Hannes Müller, Thomas Ratschiller, Wolfgang Schimetta, Jens Meier, Hans Gombotz, Andreas ZiererBackgroundJehovah’s Witnesses (JW) refuse allogeneic blood transfusions and therefore pose a unique challenge in case of major surgery. This retrospective study reviewed an experience with JW patients who were undergoing open heart surgery.MethodsBy using patient blood management strategies, 35 adult JW patients underwent cardiac surgery at Kepler University Hospital in Linz, Austria between 2008 and 2017. Outcomes were...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
FRIDAY, Sept. 20, 2019 -- Women who suffer from anemia early in pregnancy are at risk for having a child with autism, attention-deficit/hyperactivity disorder (ADHD) and intellectual disabilities, a study by Swedish researchers suggests. The study...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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