Psychosis in Borrelia burgdorferi infection - part I: epidemiology, pathogenesis, diagnosis and treatment of neuroborreliosis.

Psychosis in Borrelia burgdorferi infection - part I: epidemiology, pathogenesis, diagnosis and treatment of neuroborreliosis. Psychiatr Pol. 2019 Jun 30;53(3):629-640 Authors: Brodziński S, Nasierowski T Abstract Borreliosis is a multisystem, bacterial, zoonotic infectious disease with diversified spectrumof symptoms, which may also include psychotic disorders. Clinical picture of the disease is often unspecific, which makes the diagnosis relatively difficult. Uncharacteristic process of borreliosis is a result of complex molecular strategies used by spirochetes to infect, disseminate and survive in host organism. Part I of the article is focused on the current knowledge about pathogenesis of Lyme Borreliosis (LB), especially neuroborreliosis. Additionally, epidemic situation in Poland and in Europe was presented. Also, typical clinical manifestations of LB were described. In the article, the crucial pathogenic cell mechanisms were depicted. The processes of infection and dissemination of Borrelia in host were presented. The most important strategies of evading the response of host immune system were also discussed. These mechanisms are probable cause of the chronic and uncharacteristic clinical picture of the disease, as they significantly impair host immune response to bacteria. Also, there were presented molecular processes of neural cells impairment, which may lead to observed clinical symptoms of neuroborreliosis. Furthermore, diagnostic methods, t...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research

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This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Pu Chun Ke, Ruhong Zhou, Louise C. Serpell, Roland Riek, Tuomas P. J. Knowles, Hilal A. Lashuel, Ehud Gazit, Ian W. Hamley, Thomas P. Davis, Marcus F ändrich, Daniel Erik Otzen, Matthew R. Chapman, Christopher M. Dobson, David S. Eisenberg, Raffaele Mezzenga Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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This morning, I awoke to find that I had been copied on dozens of Twitter message exchanges among several people who were discussing the pathology of Borrelia burgdorferi, the bacterium that causes Lyme disease, among human beings and mice. My first thought was "Seriously?! It's too early for this!" My second thought was "well, David, your Twitter sure has evolved from your pre-Lyme days when you used it mostly to promote vapid celebrity interviews." As I began my morning caffeine ritual and read through each of the messages, I gained a new appreciation for some of the real complexities of "in...
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