High expression of VAT1 is a prognostic biomarker and predicts malignancy in glioblastoma.

High expression of VAT1 is a prognostic biomarker and predicts malignancy in glioblastoma. Oncol Rep. 2019 Aug 12;: Authors: Shan X, Wang K, Tong X, Wang Z, Wu F, Liu X, Yang P, Wang J Abstract Vesicle amine transport protein 1 (VAT1) has been reported as a pathogenic factor in a variety of tumors. VAT1 has been revealed to be upregulated in glioblastoma (GBM) and promotes cell migration. However, the possible mechanism of VAT1 in promoting malignant development in GBM is unclear. The present study applied transcriptome data and functional experiments to explore the exact role of VAT1. Kaplan‑Meier survival analysis, univariate and multivariate Cox analyses were used to perform survival analysis. Furthermore, Gene Ontology analysis was used to analyze the biological implication of VAT1 expression. The in vitro experiment was performed to verify the hypothesis. The expression of VAT1 was detected in gliomas and control tissues. A functional experiment was performed and the sensitivity to TMZ was assessed after knocking down the expression of VAT1. In total, 120 patients with GBM were enrolled in the present study. The results of multivariate analysis revealed that VAT1 was an independent prognostic factor for survival. Patients with high VAT1 expression levels had shorter overall survival (P=0.009) and progression‑free survival (P=0.055) than those with low expression levels. Gene Ontology analysis revealed that the genes whi...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research