Development of herb based (Nigella sativa) eri silk nanofibrous mat for biomedical applications

Publication date: Available online 14 September 2019Source: Materials Today: ProceedingsAuthor(s): A. Muthumanickkam, S. Subramanian, M. Sathiyaraj, P. Preethi, M. AshwiniAbstractThe Nigella sativa loaded eri silk fibroin nanofibrous mat was produced by electrospinning technique. The physical and chemical characteristics of electrospun mats were studied for Scanning electron microscopy (SEM), X-ray diffraction (XRD), thermo gravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR). The antimicrobial activity and blood compatibility and drug release profile of the mats were studied. The study showed that the diameter of electrospun fibre increases, thermal stability decreases, percentage crystallinity decreases and antimicrobial property increases with increase in concentration of herb. The mats have hemo-compatibility and 1.5% drug loaded nanofibrous mat showed higher sustainable drug release than that of the 1% herbal loaded nanofibrous mats.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research