Low-dose propranolol and exercise capacity in postural tachycardia syndrome: A randomized study

Conclusions:
These findings suggest that nonselective β-blockade with propranolol, when used at the low doses frequently used for treatment of POTS, may provide a modest beneficial effect to improve heart rate control and exercise capacity.

Classification of evidence:
This study provides Class II evidence that a single low dose of propranolol (20 mg) as compared with placebo is useful in increasing maximum exercise capacity measured 1 hour after medication.

Source: Neurology - May 20, 2013 Category: Neurology Authors: Arnold, A. C., Okamoto, L. E., Diedrich, A., Paranjape, S. Y., Raj, S. R., Biaggioni, I., Gamboa, A. Tags: Autonomic diseases, Cardiac, Class II ARTICLE Source Type: research