FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.

CONCLUSION: Our findings support the genetic basis of phenotypic heterogeneity in people exposed to trauma. Furthermore, the results reveal the possibility that the variants of FKBP5 gene may be associated with depression-PTSD comorbidity. PMID: 31510784 [PubMed - as supplied by publisher]
Source: Canadian Journal of Psychiatry - Category: Psychiatry Authors: Tags: Can J Psychiatry Source Type: research

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Source: TIME: Science - Category: Science Authors: Tags: Uncategorized onetime psychology syndication Source Type: news
V Casalita, Y IrawatiNigerian Journal of Clinical Practice 2019 22(9):1307-1310 Midfacial fracture is discontinuity of the bone affect maxilla, palate, zygomatico-maxillary complex, nasal bones, orbits, nasal-orbital-ethmoid complex, and frontal sinus. Delayed treatment can lead to malunion or nonunion bone. A 28 years old man presented with epiphora of the left eye and upgaze diplopia. There were enophthalmos, hypoglobus of the left eye, flat nasal bridge, and depressed left malar eminence. CT scan examination revealed multiple fractures of left nasal bone, left and right anterolateral wall of maxillary sinuses, left med...
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Conclusions[11C]PHNO BPND is abnormal following TBI, which indicates post-traumatic changes in D2/D3 receptors. Patterns of [11C]PHNO BPND seen in patients with and without MDD suggest that further research would be beneficial to determine whether the use of dopaminergic treatment might be effective in the treatment of post-traumatic depression.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Researchers at Massachusetts General Hospital used a 7 Tesla MRI Scanner to capture the most precise and detailed 3-D photo of the brain ever taken, according to  recently published reports. The brain used belonged to a 58-year old woman who died of pneumonia and had no known neurological condition. Her brain was stored for nearly three years before researchers decided to scan it for 100 hours, producing unprecedented images that could zero-in on material that was .1 millimeters wide. The brain was held in a custom-made spheroid case made of urethane, which permitted interfering air bubbles to escape. The ca...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
AbstractThere is a need to improve the understanding of the neurobiological underpinnings of traumatic brain injury (TBI). Individuals with TBI experience comorbidities such as posttraumatic stress disorder (PTSD) with considerable symptom overlap including depression and hyperarousal, confounding the ability to identify specific TBI-related brain changes. The aims of the current study were to investigate hippocampal and amygdalar volumes in Veterans with TBI with (TBI  + PTSD,n = 32) and without (TBI - PTSD,n = 25) PTSD. Shape analysis was employed to reveal any relationship betwe...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Could the advancement of machine and deep learning algorithms be harnessed meaningfully in the area of mental health? Could depression, bipolar disorder, schizophrenia, or any other mental disorder be quantified so that technology could somehow add positively to their diagnostics or treatment? We tried to explore the uses of artificial intelligence in mental health care, and stumbled upon smart algorithms that support clinicians with early detection and diagnostics of mental health issues, with the flagging of suicide risks, and other ones that help patients manage their condition through counselling and constantly being t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI artificial intelligence bipolar disorder chatbots future of psychiatry mental disorder mental health mental health disorders mental health issues moodkit pacifica schizophrenia suicide thriveport woebot Source Type: blogs
Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) to compare with...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Conclusions: Higher mGluR5 availability as a function of current SI was observed in the PTSD group only, implicating mGluR5 dysregulation as a possible state marker of SI specific to individuals with PTSD. Further, it appears individuals with PTSD may have higher mGluR5 availability as compared to the MDD group. These preliminary findings point to mGluR5 as a potential treatment target for PTSD, and to reduce SI in PTSD specifically.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
PET scans show a clear pattern of an overactive neurotransmitter in the brains of people with PTSD and suicidal thoughts, according to new research from Yale University.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Synaptic loss produced as a consequence of chronic stress contributes to the emergence of depressive-like behavior in animals. Reduced synaptic density and deficits in cortical functional connectivity are also hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). We can now quantify synaptic density in vivo by measuring synaptic vesicle glycoprotein 2A (SV2A) with the radioligand [11C]UCB-J and positron emission tomography (PET).
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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