Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress.

Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. Neurochem Res. 2019 Sep 11;: Authors: Fu J, Peng L, Wang W, He H, Zeng S, Chen TC, Chen Y Abstract Endoplasmic reticulum (ER) stress has been indicated to be involved in the pathogenesis of epilepsy. Sodium valproate (VPA), one of the most commonly used antiepileptic drugs, is reported to regulate ER stress in many neurological diseases. However, the effect of VPA on ER stress in epilepsy remains unclear. The current study was performed to investigate the role of ER stress in the neuroprotection of VPA against seizure induced by pentylenetetrzole (PTZ). Our results showed that VPA treatment could inhibit the increased expressions of ER stress proteins (GRP78 and CHOP), and significantly reduce neuronal apoptosis in the PTZ-induced experimental seizure model. In addition, Salubrinal, an ER stress inhibitor, was used as a positive control, and exhibited neuroprotective effects via inhibiting excessive ER stress in the seizure model, which further supported that the inhibition in ER stress by VPA treatment could exert neuroprotection in seizures. In summary, our work demonstrated for the first time that ER stress was involved in the neuroprotective potential of VPA for seizures. PMID: 31512113 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

Related Links:

Publication date: Available online 15 November 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Jonathan M. Beard, Penny E. Shockett, John P. O'ReillyAbstractSlow inactivation in voltage-gated Na+ channels (Navs) plays an important physiological role in excitable tissues (muscle, heart, nerves) and mutations that disrupt Nav slow inactivation can result in pathophysiologies (myotonia, arrhythmias, epilepsy). While the molecular mechanisms responsible for slow inactivation remain elusive, previous studies have suggested a role for the pore-lining D1-S6 helix. The goals of this research were to determ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Sang-Ahm Lee, Ji Ye Jeon, Hyun-Woo KimAbstractPurposeClinical trials have demonstrated the efficacy of perampanel for the treatment of epilepsy. However, patients treated with this and other antiepileptic drugs often exhibit aggressive behaviors. We investigated the clinical factors contributing to aggression in patients with refractory focal epilepsy during 6 months of adjunctive perampanel treatment.MethodsThis was a single-center longitudinal study involving patients treated with perampanel (starting dose, 2 mg/day; maximal dose, 12...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study aimed to evaluate the attention and inhibitory control functions in patients with genetic generalized epilepsy (GGE) and psychogenic nonepileptic seizure (PNES) and compare the results with the healthy control subjects. A total of 30 patients with GGE, 30 patients with PNES, and 32 healthy control subjects were included in the study. The severity of attention and inhibitory control deficit, general intelligence status, and psychopathology screening in all subjects were respectively investigated with the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT), the Wechsler Adult Intelligence Scale (W...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 16 November 2019Source: Epilepsy &BehaviorAuthor(s): Eduardo Henrique Peiruque KickhöfelAbstractRenaissance was a period full of religious and supernatural concepts and practices distant from the contemporary scientific world. Some erratic behaviors were considered demonic possessions and treated by exorcisms. It is supported by many sources. However, some important sources of the Renaissance point to a different picture. They show trends towards naturalistic explanations of many diseases, including epilepsy. This critical review discusses this approach, using texts by Mondino de...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, there is an increasing body of evidence suggesting that circuits responsible for memory consolidation during sleep seem to be gradually coopted and degraded in TLE.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 15 November 2019Source: Epilepsy &BehaviorAuthor(s): Jane Hanna, Mike Kerr, Arjune Sen
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Fraser-Rini J, Ochoa J PMID: 31726919 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
In this report, acupoint embedding method was used for a 25-year-old female patient with epilepsy. The patient suffered from repeated paroxysmal unconsciousness combined with convulsions of four limbs for 13 years, and exacerbation for 2 months. She was orally administered with antiepileptic drugs which showed poor control. Using the treatment principles of regulating the mind, opening the orifices, extinguishing wind, and relieving epilepsy, suture-embedded acupoints include Dàzhuī (大椎GV14), Băihuì (百会GV20), Xuánlú (悬颅GB5), Yāoqí (腰奇EX-B9), Gānshū (肝俞BL18), Jiūw...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Publication date: Available online 15 November 2019Source: Neurología (English Edition)Author(s): A.B. Gil Guerra, M. Rodríguez Velasco, R. Sigüenza González, M.A. Sánchez Ronco
Source: Neurologia - Category: Neurology Source Type: research
In this study, through the lens of PwE, the Irish epilepsy care setting was explored to understand its capacity to adopt a new paradigm of integrated PCC. Focus groups and semi-structured one-to-one interviews were employed to capture the qualitative experiences of a sample of Irish PwE (n = 27) in the context of the care that they receive. Participants were from different regions of the country and were aged between 18 and 55 years with 1 to 42 years since diagnosis (YSD). Highlighting a gap between policy intent and action on the ground, findings suggest that patient readiness to adopt a new model of care cannot ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
More News: Brain | Epilepsy | Neurology | Neuroscience | Sodium | Study