Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.

CONCLUSIONS: Our study demonstrates that smoke-regulated Sgms2 gene expression influences key COPD features in mice including airway resistance, AKT signaling and protease production.
PMID: 31517509 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory Cell and Molecular Biology - September 12, 2019 Category: Molecular Biology Authors: Gupta G, Baumlin N, Poon J, Ahmed B, Chiang YP, Railwah C, Kim MD, Rivas M, Goldenberg H, Elgamal Z, Salathe M, Panwala AA, Dabo A, Huan C, Foronjy R, Jiang XC, Wadgaonkar R, Geraghty P Tags: Am J Respir Cell Mol Biol Source Type: research