Synthesis, Characterization and Evaluation of Cytotoxic Activity of Novel Aziridinyl Phosphonic Acid Derivatives.

Synthesis, Characterization and Evaluation of Cytotoxic Activity of Novel Aziridinyl Phosphonic Acid Derivatives. Chem Biodivers. 2019 Sep 12;: Authors: Dogan Ö, Khan R, Ulusan S, Banerjee S Abstract New aziridine 2-phosphonic acids were prepared by mono hydrolysis of the aziridine 2-phosphonates that were obtained by the modified Gabriel-Cromwell reaction of vinyl phosphonate or alpha-tosylvinyl phosphonate with a primary amine or a chiral amine. The cellular cytotoxicity of these compounds was tested against the HCT-116 colorectal cancer cell line and the CCD-18Co normal colon fibroblast line using the MTT assay.  Three of the synthesized phosphonic acid derivatives 2e, 2h and 2i showed higher cytotoxicity than the reference cancer treatment agent etoposide. Cell death was through a robust induction of apoptosis even more effectively than etoposide, a well-known apoptosis inducing agent. PMID: 31512351 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research