Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab

ConclusionsImmunosuppression resulted in clinical remission of each irAE, highlighting the importance of vigilance for autoimmune complications in patients treated with checkpoint inhibition, even after immunotherapy cessation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research

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We describe a contiguous gene deletion of the ATM locus in a multi-generation family of Italian descent with a strong family history of pancreatic cancer. A deletion of one copy of the entire ATM gene was identified by routine panel testing and further characterized by chromosomal microarray analysis. An 11q22.3 microdeletion of approximately 960kb was identified that is predicted to result in loss of 10 genes including ATM. The deletion was identified in two additional family members including a presymptomatic daughter and an affected sibling. A normal disomic complement of the 11q22.3 region was detected in a third famil...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 October 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Q. Xu, M. Lv, Y. Xia, Y. Zhao, W. Zhang, Y. ChenAbstractA 42-year-old woman presented with a ten-day history of dysphagia, slight chest pain and occasional vomiting. With the performance of thoracic and abdominal enhanced computed tomography (CT) and upper gastrointestinal contrast, once esophageal cancer was suspected. Significant activity mass in esophagus and mediastinal lymph nodes could be found on the imaging of 18F-FDG PET/CT, which also supported malignancy. However, T...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation. Targeting IQGAP3 may contribute to the study of natural phytochemicals as anti-tumor drugs in BC. PMID: 31605603 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS PVT1 exerts an oncogenic role through activating Wnt/ß-catenin signaling in pituitary adenoma cells. The present results may provide a potential therapeutic target or approach for treating pituitary adenomas. PMID: 31604907 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS lncRNA TSLNC8 remarkably inhibited the proliferation and migration and accelerated apoptosis of lung cancer cells by targeting the IL-6/STAT3/HIF-1alpha signaling pathway. TSLNC8 may be a potential therapeutic target for the diagnosis and treatment of NSCLC. PMID: 31601776 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsIn patients with PCR, iBMEC may represent true isolated recurrence while in those with residual nodal disease, iBMEC may actually be the first observed site of widespread metastasis. Patients that received neoadjuvant therapy, especially with PCR, may benefit from brain imaging, both preoperatively and with routine surveillance.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 12 October 2019Source: Veterinary MicrobiologyAuthor(s): E. Blázquez, C. Rodríguez, J. Ródenas, N. Navarro, R. Rosell, S. Pina-Pedrero, J.M. Campbell, M. Sibila, J. Segalés, J. Pujols, J. PoloAbstractLiquid porcine plasma is an animal origin raw material for the manufacturing process of spray-dried porcine plasma that is used in pig nutrition worldwide. In previous studies we found that the application of ultraviolet light C (UV-C) in liquid plasma that was inoculated with a variety of bacteria or viruses of importance in the swine industry can be considered as...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 12 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Suganya Mani, Karthik Natesan, Kavitha Shivaji, Mythili Gnanamangai Balasubramanian, Ponmurugan PonnusamyAbstractAgeratina, adenophora, (A. adenophora) is a conventional prescription plant utilized for various purposes in around the world. However, its biological impacts and their potential components have not been adequately examined. The present investigation assessed the anticancerous properties of A. adenophora leaf extract. The methanolic extract inspired the most pronounced cytotoxic effect in lung cancer c...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Molecular LiquidsAuthor(s): Mohamed Y. El-Sayed, Hammad Fetooh, Moamen S. Refat, Hala H. Eldaroti, Abdel Majid A. Adam, Hosam A. SaadAbstractGibberellic acid (GA3) is one of the natural plant hormones. That plays versatile roles in the regulating a wide range of processes involved in plant growth and development. This work concerns the preparation, physicochemical characterization, and pharmacological properties of GA3 complexes with the ions Pt(II), Au(III), Ru(III), V(III), and Se(IV). These complexes were prepared with a 1:1 ratio at 65 °C in neu...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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