Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study

ConclusionsOur findings show thatBRCA1/2 mutations account for one in four cases of hereditary breast/ovarian cancer, one in five cases of male breast cancer, and one in eight cases of early-onset breast cancer in Pakistan. Our study suggests genetic testing of an extended panel of 21 recurrentBRCA1/2 mutations for appropriately selected patients and their families in Pakistan.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research