Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis

The objective was to review the efficacy and safety of the treatment with antifibrinolytics in patients who underwent oncologic surgeries.ContentsAn electronic bibliographic research was conducted in PubMed, OVID, MEDLINE, EMBASE, EBSCO and in the Cochrane Library data basis in order to identify randomized clinical trials performed in any type of oncologic surgery. The data evaluated were blood loss, need for transfusion and incidence of arteriovenous thromboembolism. Five randomized controlled trials evaluating 838 patients met the inclusion requirements. In the analysis of the incidence of thromboembolic events in the five RCTs, there was no statistically significant difference between the administration of tranexamic acid when compared with the placebo (OR = 0.36, 95% IC: 0.11‒1.19, p = 0.09, I2  = 0%). However, when total estimated blood loss and need for blood transfusion are analyzed, the use of tranexamic acid was associated with a significant reduction over placebo (MD = −135.79, 95% CI: −179.50 to −92.08, p 
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research

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Publication date: October 2019Source: Annals of Emergency Medicine, Volume 74, Issue 4, SupplementAuthor(s): E.L. Ha, J.J. Brennan, P. Birring, S. Shah, C.J. Coyne
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: October 2019Source: Annals of Emergency Medicine, Volume 74, Issue 4, SupplementAuthor(s): E.L. Ha, J.J. Brennan, P. Birring, S. Shah, C.J. Coyne
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
Condition:   Testicular Neoplasms Intervention:   Other: Review of Health Information Sponsors:   Walter and Eliza Hall Institute of Medical Research;   Royal Marsden NHS Foundation Trust;   Melbourne Health Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
;o LR Abstract Thromboembolism (TE) is a well-recognized complication of pediatric cancer and can lead to mortality and excess morbidity. There is conflicting evidence about the effectiveness and safety of thromboprophylaxis in children. We conducted a systematic literature review and network meta-analysis of primary pharmacological thromboprophylaxis in children and adolescents (0-21 years) with cancer. The primary outcomes were objectively proven TE and major bleeding. The network meta-analysis included comparisons of multiple alternatives simultaneously: antithrombin (AT) replacement, low molecular weight hepar...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
PMID: 31600806 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
CONCLUSION: Higher VAT rather than SAT is associated with an increased risk of unsuspected pulmonary embolism on routine CT scans in hospitalized gastrointestinal cancer patients. ADVANCES IN KNOWLEDGE: Our findings indicate that VAT is a stronger risk factor for unsuspected pulmonary embolism than BMI and SAT in hospitalized patients with gastrointestinal cancer. PMID: 31595778 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Erratum to 'A Systematic Review and Meta-Analysis of the Efficacy and Safety of Anticoagulation in the Treatment of Venous Thromboembolism in Patients With Cancer' [European Journal of Vascular &Endovascular Surgery 57/5 (2019) 685-701]. Eur J Vasc Endovasc Surg. 2019 Oct 05;: Authors: Kirkilesis GI, Kakkos SK, Tsolakis IA PMID: 31594697 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
In conclusion, homozygosity at the FGG variant and active cancer yielded synergistic effect on the risk of venous thromboembolism. PMID: 31582554 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Acute onset upper extremity edema can pose a diagnostic challenge for the emergency physician, with conditions ranging from mild local allergic reactions to deep venous thrombosis to underlying life threatening conditions. We discuss a case of a 10-year-old female with upper extremity edema and the diagnostic considerations, which ultimately led to uncovering a malignant etiology. This case represents a rare presentation of her underlying diagnosis, anaplastic large cell lymphoma.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Illustrative Cases Source Type: research
AbstractBackgroundImmunotherapy has yield only modest clinical efficacy in glioma so far. However, gliomas are characterized by a range of immune suppressive features. Here, we aimed to analyze the correlation of systemic inflammation with local tumor characteristics and overall survival in glioma patients.MethodsGlioma patients were recruited at time of diagnosis or recurrence within the Vienna Cancer and Thrombosis Study (CATS). At study inclusion, a blood draw was performed. IDH1 mutation, PD-L1 and podoplanin in glioma were assessed via immunohistochemistry.Results193 glioma patients (4.7% diffuse glioma, 19.7% anaplas...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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