Giardia excretory-secretory proteins modulate the enzymatic activities of mast cell chymase and tryptase

ConclusionOur finding suggests that Giardia ssp. via enhancement or reduction of mast cell protease activity may modulate mast cell-driven intestinal immune responses. ESP-mediated modulation of the mast cell specific proteases may also increase degradation of tight junctions, which may be beneficial for Giardia ssp. during infection.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research